The Main Line Chamber of Commerce | 4,084 followers on LinkedIn. In its 101st year, The Main Line Chamber of Commerce connects with Business, Leadership Development and Talent. | The Main Line Chamber of Commerce is the area's influential business advocate committed to ENABLING members to succeed, PROMOTING economic growth in the region, DEVELOPING an informed business community, and ENHANCING the quality of life on the Main Line. The reasons that businesses join the Main Line Chamber can vary greatly from one business to the next. Certainly, a business's geographic location can be a factor.