sïParadigm Diagnostic Informatics | 14,087 followers on LinkedIn. Service, Integrity, and Innovation | With over 18 years of experience in the medical field. sïParadigm has built a legacy in laboratory testing solutions based on scientific excellence, innovation, and world-class service. siParadigm has earned national accreditation from CLIA and CAP, as well as local licensing in several states. Our test menu achieves maximum coverage for potentially actionable aberrations such as: Single Nucleotide Variants (SNVs) , Insertions & Deletions (InDels), Copy Number Variants (CNVs), Gene Fusions (RNA), Splice Variants (RNA), Somatic and germline Homologous Recombination Deficiency (HRD) and Loss of Heterogeneity (LOH) for Specific genomic signatures: Tumor Mutation Burden (TMB) and Microsatellite Instability (MSI).