Nathan S. Kline Institute for Psychiatric Research | 473 followers on LinkedIn. As one of the nation’s most respected research centers focused on mental health, investigators at the Nathan S. Kline Institute for Psychiatric Research (NKI) study the causes, treatment, prevention, and rehabilitation of severe and persistent mental illnesses. As a facility of the New York State Office of Mental Health, founded in 1952, NKI has earned a reputation for its landmark contributions in psychiatric research, especially in the areas of psychopharmacological treatments for schizophrenia and major mood disorders, dementia research, clinical trials methodology, neuroimaging, therapeutic drug monitoring, and the application of computer technology to mental health services.